Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue

Brown adipose tissue (BAT), a major site for mammalian non-shivering thermogenesis, could be a target for prevention and treatment of human obesity. Transient receptor potential vanilloid 2 (TRPV2), a Ca2+-permeable cation channel, plays vital roles in the regulation of various cellular functions. Now researchers have revealed that lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue.